A ramdomized trial of parenteral metotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate.
Ruperto N, Murray KJ, Gerloni V, Wulffraat N, Knupp S, Falcini F, Dolezalova P, Alessio M, Burgos-Vargas R, Corona F, Vesely R, Foster H, Davidson J, Zulian F, Asplin L, Baildan E, García-Consuegra J, Ozdogan H, Saurenmann R, Joos R, Pistorio A, Woo P, Martini A, for the Pediatric Rheumatology International Trials Organization.
Arthritis Rheum 2004; 50: 2191-2201